Repaglinide (RPG) is a non-sulfonylurea oral hypoglycemic agent, mainly used in the management of type II diabetes mellitus. In this work a new attempt was made to enhance the solubility and dissolution rate of poorly soluble Repaglinide via complexation with β-cyclodextrins using various techniques and the feasability of employing Repaglinide inclusion complex in the design of mucoadhesive tablets using various mucoadhesive polymers for sustained release. The phase solubility studies indicated the formation of Repaglinide-β-cyclodextrin (1:1) inclusion complex with a stability constant of 293M-1. Mucoadhesive tablets formulated employing polymers gave slow, controlled and complete release spread over a period of 12 hrs. Drug release from the tablets followed first order kinetics upto 85-90% release and the release was diffusion controlled. The mechanism of drug release was by non Fickian diffusion. Tablets were evaluated for physical parameters, in-vitro dissolution studies, ex-vivo residence time, mucoadhesive strength and swelling index. The optimized inclusion complex and mucoadhesive tablet were evaluated by FTIR, SEM, DSC and XRD studies.
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